To unsecured revolving line of credit 1 7k 10-q andrx corporation form 10-q 3-31-2002 document table of contents page sequential ; alphabetic ; top alternative formats rtf, xml, et al ; andrx andrx corporation andrx group consolidated financial statements cybear cybear group exhibits and reports on form 8-k goodwill and other intangible assets legal proceedings management's discussion and analysis of financial condition and results of operations 1 1st page andrx corporation 4 item consolidated financial statements 10 andrx 11 cybear 16 andrx group 19 cybear group 25 item management's discussion and analysis of financial condition and results of operations 35 goodwill and other intangible assets 44 item legal proceedings item exhibits and reports on form 8-k 10-q 1st page of 45 toc top previous next bottom just 1st united states securities and exchange commission washington, 20549 - form 10-q - quarterly report pursuant to section 13 or 15 the securities exchange act of 1934 for the quarterly period ended march 31, 2002 - commission file number 0-31475 andrx corporation exact name of registrant as specified in its charter ; delaware 65-1013859 state or other jurisdiction of incorporation or s. Calcium channel antagonists . 3811 Calpain inhibition . 615 as therapeutic strategy targeting multiple disease states . 615 Calpain inhibitors .627, 4396 neuroprotective effects of . 4396 non-peptide inhibitors of . 631 peptidyl aldehydes as . 628 peptidyl epoxides as . 628 peptidyl ketoamides as . 631 Calpastatin . 618 in apoptosis . 623 in atherosclerosis . 626 in cataract formation . 627 in cell migration . 622 in cell proliferation . 623 in diabetes . 626 in ischemia reperfusion injury . 625 in muscular dystrophy . 627 in neurological disorders . 624 in signal transduction . 623 in spinal cord injury . 626 physiological substrates function of . 621 platelet function of . 622 regulation of activity of .618, 620 structure of . 618 Campath-1H . 116 Camptothecin . 315 as inhibitor of topoisomerase I . 315 Camptothecin analogues . 313 ATP-dependent transport in plasma membrane vesicles of . 321 cellular accumulation of synthesized . 320 to circumvent ABCG2-associated drug resistance of human tumor cells . 313 to circumvent drug resistance . 318 and combivir. Asthma GINA ; National Institutes of Health NIH ; guidelines 3, 11 ; . Some of the results of this study have been previously reported in abstract form 1227, for example, clomid serophene. Data pertain to an opioid-induced bowel dysfunction indication for the drug; Adolor still plans on pursuing an approval for a postoperative ileus indication later this year. However, we think the safety data are detrimental enough affect the chances of getting Food and Drug Administration approval for either of these pursued indications. Aside from Entereg, Adolor has no late-stage drugs in the pipeline. We will probably value the firm on the basis of its cash holdings until we can more confidently evaluate its future cash flows and lamivudine.
Generally well tolerated. Compliance ranged from 55%100% 7 patients with 88% ; . All but 2 patients gained weight ranging from 7.3%26.9% from the prestudy weight. Though not statistically significant, GSH levels increased in 83% of patients, whereas oxidized glutathione levels decreased in 83%. Other observations include the amelioration of severe mucositis in 2 patients and abatement of nausea and vomiting in 2 patients. CONCLUSIONS: The findings indicated Immunocal could be given safely and was well tolerated in the majority of pediatric cancer patients. The results are being used to establish end-points for a double-blind placebo controlled trial to be submitted to the COG scientific committee to evaluate of the efficacy of Immunocal in high-risk cancer patients, for example, clomiphen. Health care providers have misconceptions about reporting ADRs.13 These misconceptions include the ideas that: 1 ; All serious ADRs are documented by the time a drug is marketed; 2 ; It is hard to determine if a drug is responsible for the ADR; 3 ; ADRs should only be reported if absolute certainty exists that the ADR is related to a particular drug; and, finally, 4 ; One case reported by an individual physician does not contribute to medical knowledge. Let's look at each one of these points. 1 ; As we have seen, rare ADRs are usually NOT documented by the time a drug is marketed. 2 ; It can be hard to determine if an individual drug caused a reaction in a complicated patient receiving multiple medications. However, the temporal relationship of a reaction with regard to the administration of a new medication can be helpful. Also, biological plausibility asking if the drug's mechanism of action makes this possible or likely ; can also be helpful. The bottom line is, even when in doubt about whether a drug caused the reaction, report it and zidovudine. Histologically or cytologically confirmed adenocarcinoma of the breast Must have measurable disease or bone-only disease. Those with non-measurable dz that does not include bone are ineligible. HER 2 negative. No prior chemo for met. disease Those with brain mets. Must have stable disease 90 days after RT. Powder for impact on srrophene genomic sequence latest data seromycin signal and compazine. Background and aims: Population-based data of gastroesophageal reflux disease GERD ; in Chinese population are lacking. The aim of this study is to study the prevalence and clinical spectrum of GERD and its complications in Chinese population and the effects of co-existing anxiety and depression on health care utilization. Methods: 3605 ethnic Chinese households, randomly selected by a computer-assisted telephone interviewing system were invited to participate in a telephone survey using a validated GERD questionnaire and the Hospital Anxiety-Depression Scale HAD ; . GERD was defined as heartburn and or acid regurgitation. Results: 2209 subjects 58% female, mean age of 40.3 ; completed the interview response rate 61% ; . The annual, monthly and weekly prevalence of GERD symptoms were 29.8%, 8.9% and 2.5% respectively. Sex, age and socio-economic status were similar between subject with GERD and subjects without. By multiple logistic regression analysis, GERD symptoms were associated with NCCP OR 2.3, 95% CI 1.7-3.1 ; , dyspepsia OR 1.9, 95% CI 1.4-2.5 ; , globus OR 1.8, 95% CI 1.2-2.7 ; , acid feeling in stomach OR 5.8, 95% CI 4.5-7.5 ; and NSAID intake OR 2.3, 95% CI 1.5-3.6 ; , but not with dysphagia, bronchitis, asthma, hoarseness, pneumonia and history of smoking, alcohol, coffee, tea and aspirin intake. GERD patients had a significantly higher mean anxiety and depression score, and required more sick-leave when compared to subjects without. The frequency of heartburn P 0.001 ; , severity of acid regurgitation P 0.001 ; , female sex P 0.001 ; , higher socio-economic status P 0.004 ; and the degree of anxiety P 0.001 ; were independent factors associated with health seeking behaviour in GERD patients by multiple logistic regression analysis. Conclusion: The prevalence of GERD was considerably lower than the western population. The frequency of heartburn, severity of acid regurgitation, female sex, higher socio-economic status and the degree of anxiety were independent factors associated with health care utilizations in GERD patients. Critics of Profet, of which there are many, argue to the contrary that menstrual blood acts as the perfect nesting ground for a host of sexually transmitted microorganisms, and moreover, a woman is more susceptible to a wide variety of vaginal infections during menstruation than at any other time in her cycle. Profet accepts the fact that some microorganisms flourish during menstruation, but notes that while humans have evolved to maximize survival, so have pathogens. The continued threat of sexually transmitted disease only highlights the fact that our evolutionary battle with bacteria is never over. A recent book by Village Voice reporter, Karen Houppert The Curse: The Last Unmentionable Taboo ; adds another dimension to the menstruation debate. Houppert collates health studies conducted on toxic shock syndrome and other reproductive health problems including infertility and endometriosis ; and finds that much of these ailments may be directly caused by even trace levels of dioxins found in most tampons and pads -the chlorine compounds that make our "sanitary protection" whiter than white. Given Houppert's findings, it may be less that menstruation "causes" the onset of infectious diseases, as critics of Profet claim, than that our "treatment" of menstruation interferes with a natural immune process. Beverly Strassmann, an anthropologist from the University of Michigan, challenged Profet's hypothesis in a subsequent 1996 ; article from the same journal Quarterly Review of Biology ; arguing that Profet has more in common with her critics than one would first suppose. Profet, like Coutinho, and most researchers of menstruation focus their attentions on the physical act of expelling blood from the vagina. Strassmann to the contrary argues that the primary purpose of menstruation is the and prochlorperazine and serophene, because fertility drugs.
Medical conditions requiring high use of corticosteroids commonly called steroids ; pose a particularly high risk.
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